When the big Czech took down Federer as a teenager in the first round of the 2004 Olympics, a month after the Swiss had claimed his second Wimbledon crown, Berdych was earmarked for superstardom.
Djokovic, who has battled a form slump in the past 12 months, revealed afterwards his elbow had been troubling him on and off for "over a year and a half".
"I hope that Novak is ok with his injury".
"I'm playing very well".
He did, though, acknowledge the scale of the task he faced.
"It's just unfortunate - but in life, these particular things happen for a reason. It's a great challenge to have the opportunity to play him". That win put Federer into the he-will-definitely-win-Wimbledon zone, as Murray and Djokovic had days to forget.
"I was not aware of this statistic". 'That's why I'm happy I've had to take my first surgery really only at 34, 35 years old.
Berdych also went on to beat Djokovic in the last four that year before eventually falling to Nadal in the final.
Cilic won his only grand slam title at the U.S. Open in 2014 and has been in the last eight at the All England Club for four straight years.
Murray, the defending champion, was the first to bow out, losing to Sam Querrey in five sets, and that too after starting the match so well.More news: Celebrate safely and smartly this Fourth of July
Federer responded with several forehand winners as well once again finishing things off up at net. I'm rested. I'm fresh. "And I think that he is just mentally on top of it. That's extremely important", he said.
"If you look at Andy just walking around he looks pretty sore at the moment", said 36-year-old Hewitt.
Yes, both men may lose ranking points and places in the standings in the meantime, but if you are playing well enough it does not matter where you are ranked.
"It's not that different", Hewitt said. "Physically I'm not fighting anything like past year with my knee", added Federer, bidding to become the tournament's oldest champion in the Open era.
"I don't know if I'm playing better this year than I have in '14, '15 when I had great runs at Wimbledon here".
"I've seen him play massive Davis Cup matches - we played in Glasgow and I think he had a bit of a back issue there".
With Andy Murray also out, Federer is a huge favourite to take the title.
Cilic believes 24th-seeded Querrey's lack of experience on the biggest stage could have a slight impact.
It looks set to be one of the matches of the tournament, so shall we begin?
Jamie - who is through to the mixed doubles semis with Martina Hingis - said: "It is true that at some point Andy is going to have to manage his workload".