And Querrey, an American seeded 24th, took full advantage, hitting 27 aces and dominating down the stretch to stun Murray, and a partisan Centre Court crowd, with a 3-6, 6-4, 6-7 (4), 6-1, 6-1 victory, earning a spot in the initial Grand Slam semifinal of his career.
The triple All England Club champion was too accomplished for Mannarino in a 6-2 7-6 (7-5) 6-4 result but, ominously, he struggled with soreness in his right arm and shoulder.
Djokovic lost a first-set tiebreak to Berdych and began experiencing real difficulty with his serve, before he chose to retire early into the second set, with the score at 6-7 (2-7) 0-2.
The delay means that the world number four and second seed for the tournament has less time to prepare for his quarter-final against Czech star Tomas Berdych.
Federer, who has yet to drop a set at Wimbledon, improved to 254-2 when winning the first two sets of a match.
The only worry for Djokovic was the pain from his shoulder, which required medical treatment during the third set.More news: Threat of North Korea firing at Aust 'low'
It has been a while since Novak Djokovic had a bit of fire in his belly - and it has been a while since the same Novak Djokovic has been in a position to contend for a major title.
In fact, Djokovic has played 51 Grand Slams in a row since his Grand Slam debut at the 2005 Australian Open.
Since then, Djokovic has added 11 more Grand Slam titles and 23 more professional wins over Berdych, although the 31-year-old showed no signs of being intimidated by the apparent improbability of his task. All except court number 1, where Rafael Nadal and Gilles Muller had a spectacular match with ended after more 4 hours of active play.
It's a testament to Tomas Berdych's longevity at the top of the game that this will be the 28th meeting between Djokovic and him. There were security reasons. I guess she's kind of like a boxer: "People think it's time for her to quit because she's too old", Oracene Price said after leaving Centre Court, where the roof was shut because of rain Tuesday. "That was the only excuse. that we were getting". But I just didn't see any logic in not playing us on the Centre Court.
Djokovic said the conditions were not unsafe, but the uneven surface could cause unpredictable bounces and affect the outcome of points and even matches. (The) referee's office was completely indecisive. "I showed him and he was not very pleased about it", Djokovic said as quoted by PTI.
"Could be. We both had a very long, very tough year, a lot of matches, a lot of emotions, a lot of things in play", he said.
"We spoke with the referee, supervisors, trying to understand the thought process that they are having", he said. I've played him many times.