Serena Williams will play her sister Venus for her seventh Australian Open title with more records within reach.
Serena won her Semi-Final match later against Mirjana Lucic-Baroni at 6-2, 6-3, Business Insider said.
Venus needed nearly three times as long to overcome world number 35 Vandeweghe, who broke the 13th seed on her first service game and won the opening set on a tiebreaker.
The siblings, arguably the two best tennis players in the world, will face each other in the final on Saturday.
It will be the ninth time that the Williams sisters have contested a Grand Slam final after they both overcame their semi-final opponents in different fashion.
The most recent title showdown between the sisters also marked Venus Williams' last Grand Slam final before this week - at Wimbledon in 2009, when Serena Williams posted a 7-6 (3), 6-2 victory.
It will be the 29th major final for Serena since making her Grand Slam debut in Australia in 1998, and she powered through to the decider without dropping a set.More news: The UK Parliament Will Get A Chance To Weigh In On Brexit
Serena holds a 6-2 edge against her sister in Grand Slam finals.
Her 50th career win at Melbourne Park earned her a spot in the last four for the first time in 14 years. The athlete was diagnosed with Sjogren's syndrome, an autoimmune disorder that causes fatigue and joint, in 2011 and has struggled to come back to form, having competed in her last Australian Open final in 2003.
It's official: A Williams will win the 2017 Women's Australian Open Title. She converted five of nine break points against the big-serving Vandeweghe, who converted just one of 13. She was 30-2 in finals from 2012 to 2015 - including winning her last 15 finals during that time - but was 2-3 previous year.
Venus expressed in an interview that getting to the finals "means so much" and is "more than I dreamed of". After losing the first set, the 36-year-old fought back hard to stun her unseeded 25-year-old opponent. The Age said Venus was sidelined following an arm injury and an auto-immune illness. Reporter: She is the oldest to compete at the aussie open final and has no plans of riding off into the sun set. "I'm going to try to play my best because I know he's playing with high confidence". She has a pretty good record against me, and we have a good record against each other.
"Whoever wins, I'm just so excited that I have an opportunity to play again", Williams said.
"I think why people love sport so much, is because you see everything in a line", she said. I'd like to keep that going.